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KMID : 0984720030350040205
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Infection and Chemotherapy
2003 Volume.35 No. 4 p.205 ~ p.210
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Clinical Usefulness of Serum (1→3)-β-D-glucan Measurement in the Diagnosis of Fungemia
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Choi Suk-Hoon
Han Sang-Hoon
Chin Bum-Sik
Park Yoon-Sun
Cho Byoung-Chul
Kim Hee-Man
Kim Yoon-Jae
Lee Kkot-Sil
Jang Gyeong-Hui
Song Young-Goo
Kim June-Myung
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Abstract
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Background: Early recognition of fungemia is essential for successful treatment. However, methods to culture fungus specimen taken from fungemia patients are difficult and time consuming. To assess the clinical usefulnes s of β-D-glucan in the detection of fungemia, we compared serum (1→3)-β-D-glucan concentrations in fungemia, bacteremia, and healthy persons.
Methods: From August 2001 to October 2002, serum (1→3)-β-D-glucan concentrations were measured by turbidometric assay in 16 fungemia patients, 13 bacteremia patients and 18 healthy persons. Differences in (1→3)-β-D-glucan concentrations between fungemia patients and other groups were compared by t-test.
Results: Fungemia patients were composed of 10 male and 6 female patients, and mean age was 52.9±16.2 years. The cut-off value for a positive result was 11 pg/mL. thirteen out of 16 fungemia patients had concentrations above the cut-off value (range: 11.5-863 pg/mL, sensitivity:81.3%, specificity: 100%), and mean concentration in fungemia was 217.8±273.8 pg/mL. Mean concentration in bacteremia was 0.1±0.3 pg/mL, and all the patients with bacteremia had the concentrations below the cut-off value. Mean concentration in the healthy persons was 0 pg/mL and all healthy persons had concentration below the cut-off value. The concentration in fungemia was statistically significantly higher than those of the other two groups(p-value: respectively 0.006, 0.006).
Conclusion: We concluded that serum (1→3)-β-D-glucan is useful for the diagnosis of fungemia Further study on the usefullness of serum (1→3)-β-D-glucan for early detection of fungemia and therapeutic monitoring is warranted.
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KEYWORD
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(1→3)-β-D-glucan, fungemia, fungus, fungal infection
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